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dc.contributor.authorFratelli, Caroline Ferreira-
dc.contributor.authorSiqueira, Jhon-
dc.contributor.authorSilva, Calliandra Maria de Souza-
dc.contributor.authorFerreira, Eduardo Antônio-
dc.contributor.authorSilva, Izabel Cristina Rodrigues da-
dc.date.accessioned2021-02-17T13:52:48Z-
dc.date.available2021-02-17T13:52:48Z-
dc.date.issued2020-10-26-
dc.identifier.citationFRATELLI, Caroline et al. 5HTTLPR genetic variant and major depressive disorder: a review. Genes, v. 11, n. 11, 1260, 2020. DOI: https://doi.org/10.3390/genes11111260. Disponível em: https://www.mdpi.com/2073-4425/11/11/1260. Acesso em: 17 fev. 2021.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/40077-
dc.language.isoInglêspt_BR
dc.publisherMDPIpt_BR
dc.rightsAcesso Abertopt_BR
dc.title5HTTLPR genetic variant and major depressive disorder : a reviewpt_BR
dc.typeArtigopt_BR
dc.subject.keywordPolimorfismo (Genética)pt_BR
dc.subject.keyword5HTTLPRpt_BR
dc.subject.keywordFatores de riscopt_BR
dc.subject.keywordSistema nervosopt_BR
dc.subject.keywordFarmacogenômicapt_BR
dc.subject.keywordTranstorno depressivo maiorpt_BR
dc.rights.license© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).pt_BR
dc.identifier.doihttps://doi.org/10.3390/genes11111260pt_BR
dc.description.abstract1Major Depressive Disorder (MDD) is a disease that involves biological, psychological, and social interactions. Studies have shown the importance of genetics contribution to MDD development. The SCL6A4 protein (5HTTLPR) functions transporting serotonin, a neurotransmitter linked to mood and emotion, to the synaptic cleft. Hence, this study seeks, through a literature review, a better comprehension of the 5HTTLPR genetic variant association with MDD. For this purpose, a search was performed on the Virtual Health Library Portal for articles that related 5HTTLPR to MDD. Most of the articles found were conducted in the American continent, with one (1) study implemented in Brazil. 5HTTLPR associations were found regarding changes in the nervous system, pharmacology, and risk factors seen in MDD patients. When verifying the allelic distribution, the S allele had a higher frequency in most of the studies analyzed. Despite not finding a commonality in the different studies, the tremendous genetic variation found demonstrates the MDD complexity. For this reason, further studies in diverse populations should be conducted to assist in the understanding and treatment of the disease.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0511-9452pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9064-0735pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1903-1352pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6836-3583pt_BR
Appears in Collections:FCE-FAR - Artigos publicados em periódicos
PGCTS - Artigos publicados em periódicos

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