| Élément Dublin Core | Valeur | Langue |
|---|
| dc.contributor.author | Amato, Angélica Amorim | - |
| dc.contributor.author | Rajagopalan, Senapathy | - |
| dc.contributor.author | Lin, Jean Z. | - |
| dc.contributor.author | Carvalho, Bruno de Melo | - |
| dc.contributor.author | Figueira, Ana Carolina Migliorini | - |
| dc.contributor.author | Lu, Jenny | - |
| dc.contributor.author | Ayers, Stephen D. | - |
| dc.contributor.author | Mottin, Melina | - |
| dc.contributor.author | Silveira, Rodrigo Leandro | - |
| dc.contributor.author | Souza, Paulo Cesar Telles de | - |
| dc.contributor.author | Mourão, Rosa Helena Veras | - |
| dc.contributor.author | Saad, Mário José Abdalla | - |
| dc.contributor.author | Togashi, Marie | - |
| dc.contributor.author | Simeoni, Luiz Alberto | - |
| dc.contributor.author | Abdalla, Dulcineia Saes Parra | - |
| dc.contributor.author | Skaf, Munir Salomao | - |
| dc.contributor.author | Polikarpov, Igor | - |
| dc.contributor.author | Lima, Maria do Carmo Alves de | - |
| dc.contributor.author | Galdino, Suely Lins | - |
| dc.contributor.author | Brennan, Richard G. | - |
| dc.contributor.author | Baxter, John Darling | - |
| dc.contributor.author | Pitta, Ivan da Rocha | - |
| dc.contributor.author | Webb, Paul | - |
| dc.contributor.author | Phillips, Kevin J. | - |
| dc.contributor.author | Neves, Francisco de Assis Rocha | - |
| dc.date.accessioned | 2013-05-17T19:28:10Z | - |
| dc.date.available | 2013-05-17T19:28:10Z | - |
| dc.date.issued | 2012-08-10 | - |
| dc.identifier.citation | AMATO, Angélica A. et al. GQ-16, a novel peroxisome proliferator-activated receptor (PPAR) ligand, promotes insulin sensitization without weight gain. The Journal of Biological Chemistry, v. 287, n. 33, p. 28169-28179, ago. 2012. Disponível em: <http://www.jbc.org/content/287/33/28169.full.pdf+html?sid=05080e27-cfc7-48aa-abf6-c1149dbce8ed>. Acesso em: 17 maio 2013. | en |
| dc.identifier.uri | http://repositorio.unb.br/handle/10482/13144 | - |
| dc.description.abstract | ABSTRACT | en |
| dc.description.abstract | Background: PPAR agonists improve insulin sensitivity but also evoke weight gain.
Results: GQ-16 is a PPAR partial agonist that blocks receptor phosphorylation by Cdk5 and improves insulin sensitivity in diabetic mice in the absence of weight gain. Conclusion: The unique binding mode of GQ-16 appears to be responsible for the compound’s advantageous pharmacological profile.
Significance: Similar compounds could have promise as anti-diabetic therapeutics. | en |
| dc.language.iso | Inglês | en |
| dc.publisher | The American Society for Biochemistry and Molecular Biology, Inc. | en |
| dc.rights | Acesso Aberto | en |
| dc.title | GQ-16, a novel peroxisome proliferator-activated receptor (PPAR ) ligand, promotes insulin sensitization without weight gain | en |
| dc.type | Artigo | en |
| dc.subject.keyword | Resistência à insulina | en |
| dc.subject.keyword | Diabetes | en |
| dc.subject.keyword | Medicamentos - uso terapêutico | en |
| dc.subject.keyword | Ganho/Perda de peso | en |
| dc.rights.license | The Journal of Biological Chemistry - The final version of the manuscript will be covered under the Creative Commons Attribution license (CC BY), the most accommodating of licenses offered. Click here for details.The final version of the manuscript will be released immediately on the publisher’s website and PubMed Central. Fonte: http://www.jbc.org/site/misc/Copyright_Permission.xhtml | en |
| Collection(s) : | FAR - Artigos publicados em periódicos
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